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Histology

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The liver is invested by a connective tissue capsule called GlissonĀ“s capsule. The capsule sends septa into the substance of the liver at the porta hepatis. Here it will subdivide the parenchyma (functional component of the liver) into lobules. The hepatocyte (liver cell) are arranged to form a liver lobule (often hexagonal in shape). There are different types of liver lobules: 1) Classical lobule with portal areas in the periphery and central vein in the center. Anastomosing trabeculae and sinusoids (sinusiodal lining cells + Kupffer cells) are found here. 2) Portal lobule is based on bile flow. 3) Acinus of Rappaport is based on blood flow.

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